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May 04, 2021 · The patient with the PR had previously failed autologous CAR-T cell therapy. KUR-502 has so far demonstrated a promising safety profile with no CRS, no ICANS, and no evidence of GvHD.

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Chabannon addressed the supply chain for autologous CAR T cell therapy from a hospital perspective. CAR T cells are medicinal products that are manufactured from living cells and cryopreserved as viable (but fragile) cells. This calls for highly specialized technical expertise, so hospital pharmacies should be trained.

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“Producing autologous CAR-T cells requires at least two unique types of facilities/processes. First, a virus manufacturer to produce retro- or lentivirus to modify the cells, and then also a cell manufacturing facility to process the patients’ cells, transduce them with the virus, and then expand, characterize and formulate them.

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May 04, 2021 · The patient with the PR had previously failed autologous CAR-T cell therapy. KUR-502 has so far demonstrated a promising safety profile with no CRS, no ICANS, and no evidence of GvHD.

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Mar 06, 2018 · Patients received three HAI of anti-CEA CAR-T cells (1e10 cells per dose) along with low dose IL-2 infusion (50,000 IU/kg/day, Proleukin, Prometheus). CAR-T HAI were administered via a Surefire MVI technology. The primary objective of the study was to establish the safety of the CAR-T HAI with the pressure directed MVI device.

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Nov 04, 2020 · Celyad Oncology is a clinical-stage biotechnology company focused on the discovery and development of chimeric antigen receptor T cell (CAR T) therapies for cancer. The Company is developing a pipeline of allogeneic (off-the-shelf) and autologous (personalized) CAR T cell therapy candidates for the treatment of both hematological malignancies and solid tumors.

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12 hours ago · Before study commencement in August, 2018, treatment options for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) included salvage chemoimmunotherapy followed by autologous haematopoietic stem-cell transplantation (HSCT), and anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, which was approved in 2017 for use ...

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May 04, 2021 · Patients with R/R CD19-positive malignancies have limited effective treatment options. While CD19-directed autologous CAR-T cells are now available for these patients, they are limited by a requirement for patient leukapheresis, delays to receive treatment due to the requirement for autologous manufacturing, and variable final product quality.

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Fingerprint Dive into the research topics of 'A Rapid Cell Expansion Process for Production of Engineered Autologous CAR-T Cell Therapies'. Together they form a unique fingerprint. Together they form a unique fingerprint.

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Oct 01, 2020 · Introduction of Engineered Autologous Chimeric Antigen Receptor T-cell Immunotherapy into Central Vein, Percutaneous Approach, New Technology Group 3. “Introduce Auto CAR T cell in Central Vein, Perc, New Tech 3” for short Billable Code. XW043C3 is a valid billable ICD-10 procedure code for Introduction of Engineered Autologous Chimeric Antigen Receptor T-cell Immunotherapy into Central Vein, Percutaneous Approach, New Technology Group 3 .

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Chimeric antigen receptor (CAR) engineering of T cells has revolutionized the field of cellular therapy for the treatment of cancer. Despite this success, autologous CAR-T cells have recognized limitations that have led to the investigation of other immune effector cells as candidates for CAR modification. Recently, natural killer (NK) cells have emerged as safe and effective platforms for CAR ...

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Oct 22, 2020 · The successful manufacturing and supply of an autologous T-cell product is driven by three key parameters: 1) Time for a patient cells to begin manufacturing – At Adaptimmune, this target is seven days from a patient becoming eligible for the treatment to providing a slot for apheresis and cryopreservation of their cells at the manufacturing ...

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Autologous CAR T: Learning from the First Revolution. 7. ... BCMA CAR T cells knocked out for CD52 are resistant to ALLO-647 in a complement-dependent cytotoxicity assay.

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Apr 01, 2021 · HCT or CAR T cell recipients are often immunosuppressed for months afterwards due to conditioning regimens, maintenance therapies, immunosuppressive drugs, hypogammaglobinemia, or development of graft-versus-host disease (GvHD, in allogeneic HCT recipients); these factors may lead to a blunted immune response and affect vaccine efficacy. 7-9 ...

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Functional activity of NKG2D-CAR T cells against autologous tumor. NKG2D-CAR T cells or mock-treated autologous T cells were cultured at a 1:1 ratio with autologous patient PBMCs containing AML blasts, patient BM aspirate involved by MM, ligand-negative cell lines (P815), or healthy allogeneic donor PBMCs.

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Jan 28, 2016 · Dive Brief: Dr. James Kochenderfer, a top scientist at the National Cancer Institute (NCI), thinks that the main focus of CAR-T going forward will be autologous T-cells, according to a report from FierceBiotech . A recent abstract published in the Journal of Clinical Oncology by Kochenderfer and his colleagues caused a stir this week thanks to differing interpretations of its results' implications for the CAR-T race.

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Europe CAR-T Cell Therapy Treatment Market, By Product (Autologous CAR-T Cells, Allogeneic CAR-T Cells), Structure (First Generation CAR-T Cells, Second Generation Car-T Cells, Third Generation CAR-T Cells, Fourth Generation CAR-T Cells), Targeted Antigens (Antigens on Solid Tumors, Antigens on Hematologic Malignancies, Others), Brand (Yescarta, Kymriah, Tecartus, Others), Therapeutic ... The autologous CAR-T cell approaches in the clinic today are extremely effective but have been associated with significant toxicities and are very expensive. The use of allogeneic, off-the-shelf CAR therapies using natural killer cells from several different sources will be reviewed as potentially less toxic and less expensive immune

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Jun 04, 2017 · CHICAGO — Infusion of autologous HER2-CAR T cells after lymphodepletion is safe and appears to be associated with objective clinical benefit in patients with advanced HER2+ sarcoma, according to ...

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